ARG52462

anti-Tyrosine Hydroxylase antibody

anti-Tyrosine Hydroxylase antibody for ICC/IF,Immunohistochemistry,Western blot and Human,Mammal,Mouse,Rat

Cancer antibody; Metabolism antibody; Neuroscience antibody

Overview

Product Description

Sheep Polyclonal antibody recognizes Tyrosine Hydroxylase

Tested Reactivity Hu, Ms, Rat, Mamm
Predict Reactivity Gpig
Tested Application ICC/IF, IHC, WB
Host Sheep
Clonality Polyclonal
Isotype IgG
Target Name Tyrosine Hydroxylase
Antigen Species Rat
Immunogen Native rat tyrosine hydroxylase, purified from pheochromocytoma.
Conjugation Un-conjugated
Alternate Names DYT14; TYH; Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH; DYT5b; EC 1.14.16.2

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:1000
IHCfrozen sections: 1:1000
WB1:1000
Application Note Specific for the ~60k tyrosine hydroxylase protein.
Predict reacting to most mammals and some invertebrates.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity Purified
Buffer 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol
Stabilizer 0.1 mg/ml BSA, 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 21823 Mouse TH

GeneID: 25085 Rat TH

GeneID: 7054 Human TH

Gene Symbol TH
Gene Full Name tyrosine hydroxylase
Background Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001).
Highlight Related products:
Tyrosine Hydroxylase antibodies; Tyrosine Hydroxylase Duos / Panels; Anti-Sheep IgG secondary antibodies;
Related news:
Astrocyte-to-neuron conversion for Parkinson's disease treatment
Research Area Cancer antibody; Metabolism antibody; Neuroscience antibody
Calculated MW 59 kDa

Images (2) Click the Picture to Zoom In

  • ARG52462 anti-TH antibody WB image

    Western Blot: 10 μg of rat caudate lysate showing specific immunolabeling of the ~ 60 k tyrosine hydroxylase proteins stained with TH antibody (ARG52462).

  • ARG52462 anti-TH antibody IHC image

    Immunohistochemistry: rabbit retina stained with ARG52462 anti-TH antibody showing specific labeling of tyrosine hydroxylase in green.