ARG67255
anti-Uroplakin 1a antibody [SQab30373]
anti-Uroplakin 1a antibody [SQab30373] for IHC-Formalin-fixed paraffin-embedded sections and Human
. [Uniprot]
Overview
| Product Description | Rabbit Monoclonal antibody [SQab30373] recognizes Uroplakin 1a. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab30373 |
| Isotype | IgG |
| Target Name | Uroplakin 1a |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to Human Uroplakin 1a. |
| Conjugation | Un-conjugated |
| Alternate Names | UPK1A; Uroplakin 1A; TSPAN21; Tetraspanin-21; Uroplakin-1a; Uroplakin Ia; Tspan-21; UP1A; UPIA; UPKA; UP1a; UPIa; UPKa |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | UPK1A |
| Gene Full Name | Uroplakin 1A |
| Background | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] |
| Function | Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. [Uniprot] |
| Cellular Localization | Membrane. [Uniprot] |
| Highlight | . [Uniprot] |
| Research Area | . [Uniprot] |
| Calculated MW | 29 kDa |
| PTM | Disulfide bond, Glycoprotein. [Uniprot] |
Images (1) Click the Picture to Zoom In
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ARG67255 anti-Uroplakin 1a antibody [SQab30373] IHC-P image
Immunohistochemistry: Human Carcinoma stained with ARG67255 anti-Uroplakin 1a antibody [SQab30373] at 1:100 dilution.
