Overview

Product Description	Rabbit Polyclonal antibody recognizes ZBP1
Tested Reactivity	Hu, Ms, Rat
Tested Application	WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	ZBP1
Antigen Species	Human
Immunogen	Synthetic peptide corresponding to a.a. 21-71 of human ZBP1.
Conjugation	Un-conjugated
Alternate Names	ZBP1; Z-DNA Binding Protein 1; DLM1; DAI; C20orf183; DLM-1; Tumor Stroma And Activated Macrophage Protein DLM-1; DNA-Dependent Activator Of IRFs; Z-DNA-Binding Protein 1; DJ718J7.3; DNA-Dependent Activator Of IFN-Regulatory Factors; Chromosome 20 Open Reading Frame 183

Application Instructions

Application Suggestion	Tested Application Dilution WB 1:500 - 1:2000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Observed Size	47 kDa

Properties

Form	Liquid
Purification	Affinity chromatography purified
Buffer	PBS, 0.02% sodium azide, 50% glycerol and 0.5% BSA
Preservative	0.02% sodium azide
Stabilizer	50% glycerol and 0.5% BSA
Concentration	1 mg/ml
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 58203 Mouse ZBP1 GeneID: 81030 Human ZBP1 Swiss-port # Q9H171 Human Z-DNA-binding protein 1 Swiss-port # Q9QY24 Mouse Z-DNA-binding protein 1
Gene Symbol	ZBP1
Gene Full Name	Z-DNA Binding Protein 1
Background	This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Function	Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death. [UniProt]
Cellular Localization	Cytoplasm; Nucleus. [UniProt]
Calculated MW	46 kDa
PTM	Phosphorylated. [UniProt]

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