ARG46675
anti-ZGPAT antibody
anti-ZGPAT antibody for Western blot and Human
Overview
| Product Description | Chicken Polyclonal antibody recognizes ZGPAT |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Chicken |
| Clonality | Polyclonal |
| Isotype | IgY |
| Target Name | ZGPAT |
| Antigen Species | Human |
| Immunogen | A 15 amino acid synthetic peptide within the last 50 amino acids of human ZGPAT. |
| Conjugation | Un-conjugated |
| Alternate Names | zinc finger, CCCH-type with G patch domain; ZGPAT; ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847; ZIP; Zinc finger CCCH-type with G patch domain-containing protein; G patch domain-containing protein 6 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -725°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8N5A5 Human Zinc finger CCCH-type with G patch domain-containing protein |
|---|---|
| Gene Symbol | ZGPAT |
| Gene Full Name | zinc finger, CCCH-type with G patch domain |
| Background | Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of epidermal growth factor-activated receptor activity and negative regulation of transcription by RNA polymerase II. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] |
| Function | Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 57 kDa |
| PTM | Phosphoprotein; Ubl conjugation; Acetylation. [UniProt] |
