ARG83703

Name: arigoQIK® Human BIRC3 cIAP2 ELISA Development Kit (ARG83703)
Brand: arigobio Biolaboratories
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arigoQIK® Human BIRC3 / cIAP2 ELISA Development Kit

Ordering Information

Package

Price (USD)

1 kit
(5 plates)

499.00

1 kit
(15 plates)

998.00

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Overview

Product Description	ARG83703 arigoQIK^® Human BIRC3 / cIAP2 ELISA Development Kit, includes Capture antibody, Detection antibody, Standard, and HRP-Streptavidin Solution. This ELISA Development Kit is designed for the development of sandwich ELISA to measure Human BIRC3 / cIAP2 in Serum, plasma and cell culture supernatants. For other reagents required for arigoQIK^® ELISA Development Kit, please refer ARG83524 Integral Reagent Kit (ELISA Development Kit) More aboutarigoQIK^® : ● Optimized capture and detection antibody pairs ● Reduced incubation time and wash cycles ● 2-hour quicker than conventional ELISA process ● 5- and 15-plate packages available
Tested Reactivity	Hu
Tested Application	ELISA
Target Name	BIRC3 / cIAP2
Conjugation	HRP
Conjugation Note	Substrate: TMB and read at 450 nm.
Sensitivity	0.1 pg/mL
Sample Type	Serum, plasma and cell culture supernatants.
Standard Range	0.156-10 pg/mL
Sample Volume	50 μL
Precision	Intra-Assay CV: < 10% Inter-Assay CV: < 10%
Alternate Names	BIRC3; Baculoviral IAP Repeat Containing 3; C-IAP2; RNF49; MIHC; Inhibitor Of Apoptosis Protein 1; Apoptosis Inhibitor 2; CIAP2; MALT2; API2; Baculoviral IAP Repeat-Containing Protein 3; RING-Type E3 Ubiquitin Transferase BIRC3; TNFR2-TRAF-Signaling Complex Protein 1; TNFR2-TRAF Signaling Complex Protein; Cellular Inhibitor Of Apoptosis 2; Mammalian IAP Homolog C; RING Finger Protein 49; IAP Homolog C; Hiap-1; HIAP1; Baculoviral IAP Repeat-Containing 3; EC 2.3.2.27; HIAP-1; HAIP1; IAP-1; AIP1

Properties

Storage Instruction	Store components at 4°C or -20°C. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 330 Human BIRC3 Swiss-port # Q13489 Human Baculoviral IAP repeat-containing protein 3
Gene Symbol	BIRC3
Gene Full Name	Baculoviral IAP Repeat Containing 3
Background	This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]
Function	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. [Uniprot]