ARG83768
arigoQIK® Human TNFRSF11B / OPG ELISA Development Kit
arigoQIK® Human TNFRSF11B / OPG ELISA Development Kit for ELISA and Human
Overview
| Product Description | ARG83768 arigoQIK® Human TNFRSF11B / OPG ELISA Development Kit, includes Capture antibody, Detection antibody, Standard, and HRP-Streptavidin Solution. This ELISA Development Kit is designed for the development of sandwich ELISA to measure Human TNFRSF11B / OPG in Serum, plasma and cell culture supernatants. For other reagents required for arigoQIK® ELISA Development Kit, please refer ARG83524 Integral Reagent Kit (ELISA Development Kit) More aboutarigoQIK® : ● Optimized capture and detection antibody pairs ● Reduced incubation time and wash cycles ● 2-hour quicker than conventional ELISA process ● 5- and 15-plate packages available |
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| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Target Name | TNFRSF11B / OPG |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm. |
| Sensitivity | 15.63 pg/mL |
| Sample Type | Serum, plasma and cell culture supernatants. |
| Standard Range | 31.25-2000 pg/mL |
| Sample Volume | 50 μL |
| Precision | Intra-Assay CV: < 10% Inter-Assay CV: < 10% |
| Alternate Names | TNFRSF11B, TNF Receptor Superfamily Member 11b, OCIF, Osteoclastogenesis Inhibitory Factor, Osteoprotegerin, TR1, OPG, Tumor Necrosis Factor Receptor Superfamily, Member 11b, Tumor Necrosis Factor Receptor Superfamily Member 11B, PDB5 |
Properties
| Storage Instruction | Store components at 4°C or -20°C. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
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| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O00300 Human Tumor necrosis factor receptor superfamily member 11B |
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| Gene Symbol | TNFRSF11B |
| Gene Full Name | TNF Receptor Superfamily Member 11b |
| Background | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] |
| Function | Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. [UniProt] |
| Highlight | Related news: arigoQIK, DIY your sandwich ELISA kits; |
| PTM | N-glycosylated. Contains sialic acid residues. The N-terminus is blocked. [UniProt] |
| Title | Download Link |
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| ARG83768 arigoQIK® Human TNFRSF11B / OPG ELISA Development Kit User Manual |
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