Apoptosis Marker Antibody Duo (Bcl2, Bid)
|Cat No||Component Name||Host clonality||Reactivity||Application||Package|
|ARG20055||anti-Bid antibody||Rabbit pAb||Hu||IHC, IP, WB||25 μg|
|ARG55188||anti-Bcl 2 antibody||Rabbit pAb||Hu, Ms, Rat||ICC/IF, IHC-P, WB||50 μl|
Bcl2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.
Bid is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid protein is a member of the BCL2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. (provided by RefSeq, Jul 2008)
Bcl2, BID and Bax are known to play a major role in the process of apoptosis and their dysfunction underlies carcinogenesis. Therefore, anti-Bcl2, Bid and Bax antibodies have been used in many cancer and cancer therapeutic studies.
arigo provide an Apoptosis marker Duo, ARG30269, including anti-Bcl2 and anti-Bid antibodies, is useful for user to study the correlation of Bid, Bcl2 and apoptosis.
|Target Name||Apoptosis Marker|
|Alternate Names||Apoptosis Marker antibody; Bid antibody; Bcl 2 antibody|
|Storage Instruction||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|Note||For laboratory research only, not for drug, diagnostic or other use.|
Images (6) Click the Picture to Zoom In
ARG55188 anti-Bcl 2 antibody WB image
Western blot: 30 μg of Jurkat cell lysate stained with ARG55188 anti-Bcl 2 antibody at 1:1000 dilution.
ARG20055 anti-Bid antibody WB image
Western blot: 30 µg of Jurkat cell lysate stained with ARG20055 anti-Bid antibody at 1:500 dilution.
ARG55188 anti-Bcl 2 antibody ICC/IF image
Immunofluorescence: HeLa cells stained with ARG55188 anti-Bcl 2 antibody (red) at 1:100 dilution. DAPI (blue) for nuclear staining.
ARG55188 anti-Bcl 2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat brain stained with ARG55188 anti-Bcl 2 antibody at 1:200 dilution.
ARG55188 anti-Bcl-2 antibody IHC image
Immunohistochemistry: paraffin-embedded rat brain stained with ARG55188 anti-Bcl-2 antibody at 1:200 dilution.
ARG55188 anti-Bcl-2 antibody WB image
Western blot: 30 μg of Jurkat cell lysate stained with ARG55188 anti-Bcl-2 antibody at 1:1000 dilution.