ARG30042

Phospho IRS1 (pS307) / Phospho PKC theta (pS695) Antibody Duo

Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Gene Regulation antibody; Immune System antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody

Component

Cat No Component Name Host clonality Reactivity Application Package
ARG51725 anti-IRS1 phospho (Ser307) antibody Rabbit pAb Hu, Ms, Rat IHC-P 50 μl
ARG51669 anti-PKC theta phospho (Ser695) antibody Rabbit pAb Hu, Ms, Rat WB, IHC-P 50 μl

Overview

Product Description

Insulin receptor substrate 1 (IRS-1) is a signalling adapter protein that is phosphorylated by insulin receptor tyrosine kinase. Mutations in IRS-1 are associated with type II diabetes and susceptibility to insulin resistance.

IRS-1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1 (IGF-1) receptors to PI3K / Akt and Erk MAP kinase pathways. IRS-1 also plays important biological function for both metabolic and mitogenic pathways.

IRS-1 could be phosphorylated by p70S6K, a downstream protein of Akt, at Ser-307, Ser-636, and Ser-1101 to insulin sensitivity. In addition, IRS-1 is also potentially phosphorylated by the PKCθ kinase at Ser307.

ARG30040, ARG30041 and ARG30042 IRS-1 phospho-Duos, containing antibodies recognize total IRS-1 and phosphorylated IRS-1 at Ser307 or Ser636, and PKC theta (pS695). These Duos are designed for the IRS-1 related studies; insulin related signaling and IRS-1 regulation study.

Target Name IRS1 / PKC theta
Alternate Names Phospho IRS1 (pS307) / Phospho PKC theta (pS695) antibody; Phospho Insulin receptor substrate 1 (pS307) / Phospho PKC theta (pS695) antibody; PKC theta phospho (Ser695) antibody; IRS1 phospho (Ser307) antibody

Properties

Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Full Name Phospho Insulin receptor substrate 1 (IRS1) (pS307) / Phospho PKC theta (pS695) Antibody Duo
Research Area Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Gene Regulation antibody; Immune System antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody

Images (3) Click the Picture to Zoom In

  • ARG51669 anti-PKC theta phospho (Ser695) antibody WB image

    Western Blot: extracts from 293 cells untreated or treated with PMA stained with anti-PKC theta (phospho Ser695) antibody ARG51669.

  • ARG51669 anti-PKC theta phospho (Ser695) antibody IHC-P image

    Immunohistochemistry: paraffin-embedded human lung carcinoma tissue stained with anti-PKC theta (phospho Ser695) antibody ARG51669 (left) or the same antibody preincubated with blocking peptide (right).

  • ARG51725 anti-IRS-1 phospho (Ser307) antibody IHC-P image

    Immunohistochemistry: paraffin-embedded human breast carcinoma tissue, stained with anti-IRS-1 (phospho Ser307) antibody ARG51725).