ARG10603

anti-ABCC1 / MRP1 antibody

anti-ABCC1 / MRP1 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes ABCC1 / MRP1
Tested Reactivity Hu, Ms, Rat
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name ABCC1 / MRP1
Antigen Species Human
Immunogen Synthetic peptide from Human MRP1 protein. (LLQQRGLFYSMAKDAGLV)
Conjugation Un-conjugated
Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Alternate Names GS-X; ATP-binding cassette sub-family C member 1; ABCC; Leukotriene C; ABC29; MRP; 4; LTC4 transporter; MRP1; Multidrug resistance-associated protein 1

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P0.5 - 1 µg/ml
WB0.5 - 1 µg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Calculated MW 171.5 kDa

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS, 0.025% Sodium azide and 2.5% BSA
Preservative 0.025% Sodium azide
Stabilizer 2.5% BSA
Concentration 0.5 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 17250 Mouse ABCC1

GeneID: 4363 Human ABCC1

Swiss-port # O35379 Mouse Multidrug resistance-associated protein 1

Swiss-port # P33527 Human Multidrug resistance-associated protein 1

Gene Symbol ABCC1
Gene Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Background The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
Function Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. [UniProt]
Cellular Localization Cell membrane

Images (1) Click the Picture to Zoom In

  • ARG10603 anti-ABCC1 / MRP1 antibody WB image

    Western blot: 1) Jurkat, 2) CEM, and 3) A549 cell lysates stained with ARG10603 anti-ABCC1 / MRP1 antibody.