ARG22372

anti-CD206 / MMR antibody

anti-CD206 / MMR antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Pig,Rat

Immune System antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M2 Macrophage Marker antibody
publication_link Publication2

Overview

Product Description

Rabbit Polyclonal antibody recognizes CD206 / MMR

Tested Reactivity Hu, Ms, Rat, Pig
Tested Application ICC/IF, IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name CD206 / MMR
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide from Human CD206 / MMR.
Conjugation Un-conjugated
Alternate Names CLEC13D; C-type lectin domain family 13 member D; Macrophage mannose receptor 1-like protein 1; C-type lectin domain family 13 member D-like; MMR; CLEC13DL; CD206; Macrophage mannose receptor 1; bA541I19.1; CD antigen CD206; MRC1L1

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:400
IHC-P1:100 - 1:500
WB1:300 - 1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS and 0.02% Sodium azide.
Preservative 0.02% Sodium azide
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 17533 Mouse MRC1

GeneID: 4360 Human MRC1

Swiss-port # P22897 Human Macrophage mannose receptor 1

Swiss-port # Q61830 Mouse Macrophage mannose receptor 1

Gene Symbol MRC1
Gene Full Name mannose receptor, C type 1
Background The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. CD206 / MMR is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. [provided by RefSeq, Sep 2015]
Function CD206 / MMR mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.

(Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.

(Microbial infection) Acts as a receptor for Dengue virus envelope protein E.

(Microbial infection) Interacts with Hepatitis B virus envelope protein. [UniProt]
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Research Area Immune System antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M2 Macrophage Marker antibody
Calculated MW 166 kDa

Images (10) Click the Picture to Zoom In

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat colon tissue stained with ARG22372 anti-CD206 / MMR antibody at 5 µg/ml dilution.

  • ARG22372 anti-CD206 / MMR antibody WB image

    Western blot: 1) Rat brain, 2) Rat kidney, and 3) Mouse brain tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:500 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat skin tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:200 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat skin tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:100 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat kidney tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:100 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat brain tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:200 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Pig kidney tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:200 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Pig heart tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:200 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat kidney tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:200 dilution.

  • ARG22372 anti-CD206 / MMR antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat brain tissue stained with ARG22372 anti-CD206 / MMR antibody at 1:100 dilution.

Specific References

Abrogation of Toll like receptor 4 (TLR4) mitigates obesity-induced oxidative stress, proinflammation, and insulin resistance through metabolic reprogramming of mitochondria in adipose tissue.

IHC-P / Mouse

Lin Hung-Yu et al.
Antioxid Redox Signal.,  (2020)

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Metformin enhances gefitinib efficacy by interfering with interactions between tumor-associated macrophages and head and neck squamous cell carcinoma cells.

ICC/IF / Human

Yin Xiteng et al.
Cell Oncol (Dordr).,  (2019)

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