New antibody panels and duos for Tumor immune microenvironment (TIME)

New antibody panels and duos for Tumor immune microenvironment (TIME)

 

The infiltrating immune cells in tumor microenvironment have become a crucial point in cancer research due to their association with tumor progression and suppression. The anti-tumor immune responses involve cytotoxic T lymphocytes (CTLs) and NK cells for identifying and eliminating cancer cells. In contrast, the pro-cancer immune responses involves regulatory T cells (Tregs) and tumor-associated myeloid cells (e.g., MDSCs, TAMs etc.) for supporting tumor growth and suppressing anti-tumor immune responses. Current cancer immunotherapies focus on enhancing immune cells to recognize and destroy cancer cells. Targeting immunosuppressive cell subpopulations may pave the way for future therapies.
 

arigo launches a series of antibody duos and panels for identifying tumor-infiltrating lymphocytes (TILs) (ARG30334), MDSCs (ARG30336 and ARG30335 for human and mouse respectively), M1/M2/TAMs (ARG30333), and CAF Marker Antibody Duo (ARG30322). These panels and duos are the best solution to characterize tumor immune microenvironment and facilitate the understanding of the clinical impact of tumor immune infiltration.

 

Tumor-infiltrating Lymphocyte Antibody Panel (ARG30334)
Ideal for identifying the lymphocytes in tumor tissues.

* Includes general T cell marker CD3 antibody.
* Includes cytotoxic T cell marker CD8 antibody.
* Include regulatory T cell marker CD4 antibody.
* Includes B cell marker CD20 antibody.
* Outstanding performance in IHC staining.

Component Reactivity Application Package
CD3 antibody [SQab1713] Hu FACS, ICC/IF, IHC-P, IP, WB 20 μl
CD8 antibody [SQab19146] Hu IHC-P 20 μl
CD4 antibody [SQab1714] Hu FACS, IHC-P, IP, WB 20 μl
CD20 antibody [SQab1719] Hu FACS, ICC/IF, IHC-P, IP 20 μl

 

M1/M2/TAM Marker Antibody Panel (ARG30333)
Ideal for identifying M1, M2, and tumor-associated macrophages (TAMs) in cultured cells or tissues.

* Includes the antibody markers for M1, M2, and TAMs.
* Excellent for studying macrophage polarization.
* Outstanding performance in IHC staining.
* Good for double staining.

Component Reactivity Application Package
CD68 antibody [KP1] Hu, Ms, Rat, Rb FACS, ICC/IF, IHC-Fr, IHC-P, WB 20 μg
iNOS antibody Hu, Ms, Rat, Mamm ICC/IF, IHC-P, IP, WB 50 μl
CD163 antibody [SQab19148] Hu IHC-P 20 μl
CD206 antibody [15-2] Hu, Ms FACS, ICC/IF, IHC-Fr, IP, WB 20 μg

 

Human MDSC Marker Antibody Duo (ARG30336)
Mouse MDSC Marker Antibody Duo (ARG30335)

Ideal for identifying myeloid-derived suppressor cells (MDSCs) in tumor tissues.

* Includes the key MDSC marker antibodies.
* Outstanding performance in IHC staining.
* Useful for FACS-based analysis.

Product Component Reactivity Application
Human MDSC Marker
Antibody Duo (ARG30336)
CD11b antibody [M1/70] Hu, Ms, Mk , Bb FACS, ICC/IF, IHC-Fr, IP
CD33 antibody [WM53] Hu, NHuPrm FACS, ICC/IF, IHC-Fr, IP, WB

Mouse MDSC Marker
Antibody Duo (ARG30335)

CD11b antibody [M1/70] Hu, Ms, Mk , Bb FACS, ICC/IF, IHC-Fr, IP
Gr-1 antibody [RB6-8C5] Ms FACS, IHC-Fr, IHC-P, IP

 

 

CAF Marker Antibody Duo (ARG30322)
Ideal for identifying cancer-associated fibroblasts (CAFs) in tumor tissues.

* Includes the CAF marker alpha-SMA and Vimentin antibodies.
* Good for studying myofibroblast differentiation.
* Outstanding performance in IHC staining.
* Useful on human and mouse samples.

Component Reactivity Application
alpha-SMA antibody [SQab18108] Hu, Ms, Rat, Mk, Bv, Dog, Pig, Zfsh FACS, ICC/IF, IHC-P, WB
Vimentin antibody [SQab1721] Hu, Ms FACS, ICC/IF, IHC-P, IP, WB