ARG10779

anti-DRD2 / Dopamine Receptor D2 antibody

anti-DRD2 / Dopamine Receptor D2 antibody for ELISA,ICC/IF,IHC-Frozen sections,Immunoprecipitation,Western blot and Mouse,Rat

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Overview

Product Description Rabbit Polyclonal antibody recognizes DRD2 / Dopamine Receptor D2
Tested Reactivity Ms, Rat
Tested Application ELISA, ICC/IF, IHC-Fr, IP, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name DRD2 / Dopamine Receptor D2
Antigen Species Rat
Immunogen Synthetic peptide taken within aa. 150-200 from Rat DRD2 / Dopamine D2 receptor.
Conjugation Un-conjugated
Full Name dopamine receptor D2
Alternate Names D2R; D2DR; D(2) dopamine receptor; Dopamine D2 receptor

Application Instructions

Application Suggestion
Tested Application Dilution
ELISA1:50000
ICC/IF1:200
IHC-Fr1:200
IP1:200
WB1:1000 - 1:15000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Calculated MW 51 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA.
Preservative 0.02% Sodium azide
Stabilizer 30% Glycerol and 0.5% BSA
Concentration 0.75 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 13489 Mouse DRD2

GeneID: 24318 Rat DRD2

Swiss-port # P61168 Mouse D(2) dopamine receptor

Swiss-port # P61169 Rat D(2) dopamine receptor

Gene Symbol Drd2
Gene Full Name dopamine receptor D2
Background This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
Function Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. [UniProt]

Images (2) Click the Picture to Zoom In

  • ARG10779 anti-DRD2 / Dopamine Receptor D2 antibody WB image

    Western blot: 1) Recombinant Dopamine D2 receptor protein, and 2) cerebellar membranes stained with ARG10779 anti-DRD2 / Dopamine Receptor D2 antibody at 1:500 dilution.

  • ARG10779 anti-DRD2 / Dopamine Receptor D2 antibody WB image

    Western blot: Rat striatal membranes stained with ARG10779 anti-DRD2 / Dopamine Receptor D2 antibody at 1:500 dilution.

Specific References

Chronic stress increases susceptibility to food addiction by increasing the levels of DR2 and MOR in the nucleus accumbens.

IHC-Fr / Mouse

Wei Nai-Li et al.
Neuropsychiatr Dis Treat.,  (2019)

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