ARG10382

anti-IL1 beta antibody [11E5]

anti-IL1 beta antibody [11E5] for ELISA,IHC-Formalin-fixed paraffin-embedded sections,IHC-Frozen sections and Human

Pyroptosis Study antibody

Overview

Product Description Mouse Monoclonal antibody [11E5] recognizes IL1 beta
Tested Reactivity Hu
Tested Application ELISA, IHC-Fr, IHC-P
Host Mouse
Clonality Monoclonal
Clone 11E5
Isotype IgG2b
Target Name IL1 beta
Antigen Species Human
Immunogen recombinant human IL-1, β
Conjugation Un-conjugated
Full Name interleukin 1, beta
Alternate Names Interleukin-1 beta; IL1-BETA; IL-1; IL-1 beta; Catabolin; IL1F2

Application Instructions

Application Suggestion
Tested Application Dilution
ELISAAssay-dependent
IHC-FrAssay-dependent
IHC-PAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Calculated MW 31 kDa

Properties

Form Liquid
Purification Protein A affinity purified.
Buffer PBS (pH 7.4) and 0.1% Sodium azide
Preservative 0.1% Sodium azide
Concentration 1.0-2.0 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 3553 Human IL1B

Swiss-port # P01584 Human Interleukin-1 beta

Gene Symbol IL1B
Gene Full Name interleukin 1, beta
Background IL1 beta protein is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
Function IL1 beta is a potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). [UniProt]
Highlight Related products:
IL1 beta antibodies; IL1 beta ELISA Kits; IL1 beta Duos / Panels; IL1 beta recombinant proteins; Anti-Mouse IgG secondary antibodies;
Related news:
Exploring Antiviral Immune Response
Research Area Pyroptosis Study antibody
PTM Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.

Clone References

Epinecidin-1 has immunomodulatory effects, facilitating its therapeutic use in a mouse model of Pseudomonas aeruginosa sepsis.

Pan CY et al.
Antimicrob Agents Chemother.,  (2014)

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Disease severity in patients infected with Leishmania mexicana relates to IL-1β.

IHC-Fr / Human

Fernández-Figueroa EA et al.
PLoS Negl Trop Dis.,  (2012)

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Effects of oral and vaginal administration of levonorgestrel emergency contraception on markers of endometrial receptivity.

Meng CX et al.
Hum Reprod.,  (2010)

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Severity of tubulointerstitial inflammation and prognosis in immunoglobulin A nephropathy.

Myllymäki JM et al.
Kidney Int.,  (2007)

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Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions.

Hobbs RM et al.
J Invest Dermatol.,  (2004)

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