anti-IL1 beta antibody [S1H12]
anti-IL1 beta antibody [S1H12] for ELISA,Western blot and Human
Cell Biology and Cellular Response antibody; Immune System antibody; Metabolism antibody
Mouse Monoclonal antibody [S1H12] recognizes IL1 beta
|Tested Application||ELISA, WB|
|Specificity||Does not show any cross reaction with recombinant human IL-1α, recombinant murine IL-1α or IL-1β.|
|Target Name||IL1 beta|
|Immunogen||Purified recombinant human IL-1β|
|Full Name||interleukin 1, beta|
|Alternate Names||Interleukin-1 beta; IL1-BETA; IL-1; IL-1 beta; Catabolin; IL1F2|
|Application Note||ELISA: React with human IL-1β.
WB: This antibody, when used at concentration of 20-100 ng/ml will allow visualization of 100 ng/lane of human IL-1β.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
|Calculated MW||31 kDa|
|Purification||Protein G affinity purified|
|Buffer||0.01M PBS (pH 7.2)|
|Storage instruction||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|Note||For laboratory research only, not for drug, diagnostic or other use.|
|Gene Full Name||interleukin 1, beta|
|Background||IL1 beta protein is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]|
|Function||IL1 beta is a potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). [UniProt]|
|Research Area||Cell Biology and Cellular Response antibody; Immune System antibody; Metabolism antibody|
|PTM||Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.|