ARG10791
anti-PDE1A antibody
anti-PDE1A antibody for Confocal microscopy (Confocal),Dot blot,ELISA,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,IHC-Frozen sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PDE1A |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | Confocal, Dot, ELISA, ICC/IF, IHC-Fr, IHC-P, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PDE1A |
| Antigen Species | Mouse |
| Immunogen | Synthetic peptide around aa. 1-50 from Mouse PDE1A protein. Common to all PDE1A variants. |
| Conjugation | Un-conjugated |
| Alternate Names | CAM-PDE-1A; Cam-PDE 1A; HCAM1; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; EC 3.1.4.17; HSPDE1A; hCam-1; HCAM-1; 61 kDa Cam-PDE |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 30% Glycerol and 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P54750 Human Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Swiss-port # Q61481 Mouse Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
|---|---|
| Gene Symbol | Pde1a |
| Gene Full Name | phosphodiesterase 1A, calmodulin-dependent |
| Background | Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009] |
| Function | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP. [UniProt] |
| Calculated MW | 61 kDa |
Images (2) Click the Picture to Zoom In
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ARG10791 anti-PDE1A antibody IHC-Fr image
Immunohistochemistry: Frozen Mouse kidney stained with ARG10791 anti-PDE1A antibody.
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ARG10791 anti-PDE1A antibody WB image
Western blot: Recombinant PDE1A protein stained with ARG10791 anti-PDE1A antibody at 1:500 dilution.
