Baking soda restores circadian clock in tumor cells

Baking soda restores circadian clock in tumor cells

Circadian clock controls cell cycle factors, and circadian disruption promotes cancer. Several reports indicate that hypoxia influences the circadian clock through HIF1-mediated transcriptional regulation of clock genes in tumor cells. Targeting the circadian clock is a potential strategy for cancer therapy.

Recently published in the journal Cell, Walton et al. reported that hypoxic tumor microenvironment elevates acid production that in turn scatters lysosomes, thereby silencing mTORC1 through separation from RHEB. mTORC1 inhibition by acid dampens clock network translation and collapses the clock. However, buffering the acidic environment by feeding baking soda in mouse tumor model restore mTORC1 activity and rescues circadian oscillation. Their findings reveal an anti-cancer potential of baking soda, which buffers against acidification in tumor microenvironment. (Walton et al., (2018) Cell. pii: S0092-8674(18)30586-5.)




arigo offers excellent antibodies and ELISA kits to facilitate the studies of hypoxia and circadian clock in tumor cells.

HIF-1 alpha antibody [ESEE122]

Melatonin ELISA Kit (ARG80864)
Detection: HRP

Melatonin ELISA Kit (ARG80461)
Detection: AP

mTOR antibody (ARG54727)

Raptor antibody (ARG58761)

MLST8 antibody (ARG57927)

LAMP1 antibody [H4A3] (ARG65453)

Akt antibody (ARG56418)

Akt phospho (Ser473) antibody