Mitochondria are essential for cellular energy metabolism. The PGC-1α/NRF1/TFAM axis is a central pathway regulating mitochondrial biogenesis. PGC-1α acts as a master regulator, coactivating NRF1 to induce the expression of TFAM, which promotes mitochondrial DNA (mtDNA) transcription and replication, leading to creation of new mitochondria and enhanced cellular energy production.

arigo offers Mitochondrial Biogenesis Antibody Panel that includes antibodies against key components of this pathway, supporting the investigation of mitochondria and energy metabolism.

Mitochondrial Biogenesis Antibody Panel (ARG30358)

* Includes master regulator PGC-1α antibody
* Includes key transcription factor NRF1 antibody
* Includes essential regulator TFAM antibody
* Works on human, mouse, and rat samples

PGC-1α is activated through post-translational modifications mediated by AMPK, SIRT1, and p38 MAPK. AMPK responds to low-energy conditions, SIRT1 activates PGC-1α by deacetylation, and p38 MAPK enhances its stability. arigo offers quality antibodies to support the research into the regulatory mechanisms of PGC-1α.
 

AMPKα antibody (ARG51172)

AMPKα pThr183/Thr172 antibody (ARG51678)

SIRT1 antibody (ARG40616)

p38 antibody (ARG55258)

p38 pThr180/Tyr182 antibody (ARG51850)

PGC-1α acts as a transcriptional coactivator for multiple transcription factors, especially those controlling mitochondrial biogenesis and energy metabolism. PGC-1α coactivates NRF1/2 and ERRα/γ to promote mitochondrial biogenesis, PPARγ to regulate fatty acid oxidation, and HNF4α and FOXO1 to control hepatic gluconeogenesis. arigo offers quality antibodies to facilitate advanced research into PGC-1α-mediated gene expression.