ARG20992

anti-TCR gamma + TCR delta antibody [UC7-13D5] (PE)

anti-TCR gamma + TCR delta antibody [UC7-13D5] (PE) for Flow cytometry,Depletion and Mouse

Overview

Product Description PE-conjugated Hamster Monoclonal antibody [UC7-13D5] recognizes TCR gamma + TCR delta
Tested Reactivity Ms
Tested Application Depletion, FACS
Specificity Mouse TCRγδ. The clone UC7-13D5 is specific for the γδ heterodimer and plate-bound UC7-13D5 activates γδ TCR-bearing cells. This antibody does not react with αβ TCR-expressing T cells.
Host Hamster
Clonality Monoclonal
Clone UC7-13D5
Isotype IgG3
Target Name TCR gamma + TCR delta
Species Mouse
Immunogen Mouse T cell clone G8
Conjugation PE
Full Name T cell receptor gamma locus; T cell receptor delta locus
Alternate Names TCR gamma: TCRG
TCR delta: TCRD; TCRDV1

Application Instructions

Application Suggestion
Tested Application Dilution
DepletionAssay-dependent
FACS< 0.3 µg/10^6 cells
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Calculated MW 19 kDa

Properties

Form Liquid
Buffer PBS, Sodium azide and a stabilizing agent
Preservative Sodium azide
Concentration 0.1 mg/ml
Storage instruction Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Symbol TRG; TRD
Gene Full Name T cell receptor gamma locus; T cell receptor delta locus
Background TCR gamma: T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor gamma locus. The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the gamma chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the gamma locus are known to be incapable of encoding a protein and are considered pseudogenes. Somatic rearrangement of the gamma locus has been observed in T cells derived from patients with T cell leukemia and ataxia telangiectasia. [provided by RefSeq, Jul 2008]
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Images (1) Click the Picture to Zoom In

  • ARG20992 anti-TCR gamma + TCR delta antibody [UC7-13D5] (PE) FACS image

    Flow Cytometry: C57BL/6 Mouse mesenteric lymph node cells stained with ARG20992 anti-TCR gamma + TCR delta antibody [UC7-13D5] (PE) and anti-CD3e antibody [C363.29B] (FITC).