ARG30212

Phospho Tyrosine Hydroxylase Antibody Panel (Total, pS31, pS40)

Cancer antibody; Immune System antibody; Metabolism antibody; Neuroscience antibody
publication_link Publication1

Component

Cat No Component Name Host clonality Reactivity Application Package
ARG52464 anti-Tyrosine Hydroxylase phospho (Ser40) antibody Rabbit pAb Hu, Ms, Rat, Mamm WB, ICC/IF, IHC 50 μl
ARG52463 anti-Tyrosine Hydroxylase phospho (Ser31) antibody Rabbit pAb Ms, Rat ICC/IF, IHC, WB 50 μl
ARG52461 anti-Tyrosine Hydroxylase antibody Rabbit pAb Hu, Mamm, Ms, Rat ICC/IF, IHC-P, IHC-Fr, WB 50 μl
ARG65351 Goat anti-Rabbit IgG antibody (HRP) Goat pAb Rb ELISA, IHC-P, WB 50 μl

Overview

Product Description Tyrosine Hydroxylase (TH) is an enzyme responsible for catalyzing the conversion of L-tyrosine to L-DOPA, a precursor for an important neurotransmitter Dopamine. TH activity is regulated by its phosphorylation. The phosphorylation of TH at Ser31 and Ser40 residues was found to enhance dopamine synthesis in primary neurons. Daubner, Le and Wang. 2011. Arch Biochem Biophy 508(1):1-12 Kobori et al. 2004. J Biol Chem 279(3): 2182-91

Related news:
Astrocyte-to-neuron conversion for Parkinson's disease treatment
Target Name Tyrosine Hydroxylase
Alternate Names Phospho Tyrosine Hydroxylase antibody; Tyrosine Hydroxylase antibody; Tyrosine Hydroxylase phospho (Ser31) antibody; Tyrosine Hydroxylase phospho (Ser40) antibody

Properties

Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Full Name Antibody Panel for Phospho Tyrosine Hydroxylase (Total, pS31, pS40)
Research Area Cancer antibody; Immune System antibody; Metabolism antibody; Neuroscience antibody

Images (7) Click the Picture to Zoom In

  • ARG52461 anti-Tyrosine Hydroxylase antibody WB image

    Western blot: 30 µg of Mouse brain tissue lysate stained with ARG52461 anti-Tyrosine Hydroxylase antibody at 1:500 dilution.

  • ARG52461 anti-Tyrosine Hydroxylase antibody ICC/IF image

    Immunofluorescence: E17 Rat midbrain mixed neuronal cultures stained with ARG52461 anti-Tyrosine Hydroxylase antibody (green) and ARG52328 anti-MAP2 antibody (red).

  • ARG52464 anti-Tyrosine Hydroxylase phospho (Ser40) antibody WB image

    Western blot: Recombinant phospho- and dephospho-Tyrosine Hydroxylase. The blots were stained with anti-pan Tyrosine Hydroxylase antibody and ARG52464 anti-Tyrosine Hydroxylase phospho (Ser40) antibody.

  • ARG52461 anti-Tyrosine Hydroxylase antibody IHC-Fr image

    Immunohistochemistry: Frozen section of Mouse brain stained with ARG52461 anti-Tyrosine Hydroxylase antibody at 1:1000 dilution.

  • ARG52461 anti-TH antibody WB image

    Western Blot: 10 μg of rat caudate lysate showing specific immunolabeling of the ~60k TH protein stained with TH antibody (ARG52461).

  • ARG52463 anti-Tyrosine Hydroxylase phospho (Ser31) antibody WB image

    Western blot: PC-12 cells incubated in the absence (Control) and presence of okadaic acid (OA, 1 µM for 60 min) showing specific immunolabeling of the ~60 kDa TH phosphorylated at Ser31 stained with ARG52463 anti-Tyrosine Hydroxylase phospho (Ser31) antibody.

  • ARG52464 anti-Tyrosine Hydroxylase phospho (Ser40) antibody IHC image

    Immunohistochemistry: Light-stimulated Rabbit retina stained with ARG52464 anti-Tyrosine Hydroxylase phospho (Ser40) antibody showing labeling of TH when phosphorylated at Ser40.

Specific References

Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation

ARG52461: Imaging Cytometry / Human

Yu-Che Cheng et al.
Stem Cell Rev Rep.,  (2022)

publication_link

 

hr_line