ARG30144

Phospho beta Catenin Antibody Panel (Total, pS33, pS37, pT41/pS45)

Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Neuroscience antibody; Signaling Transduction antibody
publication_link Publication3

Component

Cat No Component Name Host clonality Reactivity Application Package
ARG52651 anti-beta Catenin antibody Rabbit pAb Hu, Ms, Rat ICC/IF, IHC-P, IHC-Fr, IP, WB 250 μl
ARG51709 anti-beta Catenin phospho (Ser33) antibody Rabbit pAb Hu, Ms, Rat WB, IHC-P 50 μl
ARG51710 anti-beta Catenin phospho (Ser37) antibody Rabbit pAb Hu, Ms, Rat WB, IHC-P 50 μl
ARG51618 anti-beta Catenin phospho (Thr41 / Ser45) antibody Rabbit pAb Hu, Ms, Rat WB 50 μl
ARG65351 Goat anti-Rabbit IgG antibody (HRP) Goat pAb Rb ELISA, IHC-P, WB 50 μl

Overview

Product Description

β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Both Akt and PKA were shown to phosphorylate β-catenin at Ser552 and Ser675. Phosphorylation at Ser552 and Ser675 induces β-catenin accumulation in the nucleus and increases its transcriptional activity.This antibody panel investigates different processes through the phosphorylation on multiple site of β-Catenin.

Cadigan, K.M. and Nusse, R. (1997) Genes Dev 11, 3286-305.
Amit, S. et al. (2002) Genes Dev 16, 1066-76.
Liu, C. et al. (2002) Cell 108, 837-47.
Yanagawa, S. et al. (2002) EMBO J 21, 1733-42.
Yost, C. et al. (1996) Genes Dev 10, 1443-54.
Fang D et al. (2007) J Biol Chem 282, 11221–9.
He, X.C. et al. (2007) Nat. Genet. 39, 189-198.

Target Name beta Catenin
Alternate Names Phospho beta Catenin antibody; beta Catenin phospho (Thr41 / Ser45) antibody; beta Catenin phospho (Ser33) antibody; beta Catenin phospho (Ser37) antibody; beta Catenin antibody

Properties

Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Full Name Antibody Panel for Phospho beta Catenin (Total, pS33, pS37, pT41/pS45)
Research Area Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Neuroscience antibody; Signaling Transduction antibody

Images (8) Click the Picture to Zoom In

  • ARG52651 anti-beta Catenin antibody WB image

    Western blot: 30 µg of 1) 293T, 2) 3T3, and 3) Mouse liver lysate stained with ARG52651 anti-beta Catenin antibody at 1:500 dilution.

  • ARG51618 anti-beta Catenin phospho (Thr41/Ser45) antibody WB image

    Western Blot: extracts from SW626 cells stained with anti-beta Catenin (phospho Thr41/Ser45) antibody ARG51618 (Lane 2) and the same antibody preincubated with blocking peptide (Lane1).

  • ARG51709 anti-beta Catenin phospho (Ser33) antibody WB image

    Western Blot: extracts from MCF-7 cells untreated or treated with Calyculin A stained with anti-beta Catenin (phospho Ser33) antibody ARG51709.

  • ARG51710 anti-beta Catenin phospho (Ser37) antibody WB image

    Western Blot: extracts from HT29 cells stained with anti-beta Catenin (phospho Ser37) antibody ARG51710 and the same antibody preincubated with blocking peptide .

  • ARG52651 anti-Catenin-beta antibody WB image

    Western Blot: A431 stained with Catenin-beta antibody (ARG52651)

  • ARG51709 anti-beta Catenin phospho (Ser33) antibody IHC-P image

    Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-beta Catenin (phospho Ser33) antibody ARG51709 (left) or the same antibody preincubated with blocking peptide (right).

  • ARG51710 anti-beta Catenin phospho (Ser37) antibody IHC-P image

    Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-beta Catenin (phospho Ser37) antibody ARG51710 (left) or the same antibody preincubated with blocking peptide (right).

  • ARG52651 anti-Catenin-beta antibody IHC-P image

    Immunohistochemistry: Human Breast Carcinoma stained with Catenin-beta antibody (ARG52651)

Specific References

Diuretic Action of Apelin-13 Mediated by Inhibiting cAMP/PKA/sPRR Pathway.

ARG52651: WB / Mouse

Yanting Chen et al.
Front. Physiol.,  (2021)

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Ubiquitin specific peptidase 5 enhances STAT3 signaling and promotes migration and invasion in Pancreatic Cancer.

ARG52651: WB / Human

Jie Lian et al.
J Cancer.,  (2020)

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Narasin inhibits tumor metastasis and growth of ERα-positive breast cancer cells by inactivation of the TGF-β/SMAD3 and IL-6/STAT3 signaling pathways.

ARG52651: WB / Human

Jing Chen et al.
Molecular Medicine Reports.,  (2020)

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