anti-IL17 / IL17A antibody

anti-IL17 / IL17A antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat

Cancer antibody; Immune System antibody
publication_link Publication3


Product Description

Rabbit Polyclonal antibody recognizes IL17 / IL17A

Tested Reactivity Hu, Ms, Rat
Tested Application ICC/IF, IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name IL17 / IL17A
Antigen Species Human
Immunogen Recombinant protein of Human IL17A (NP_002181.1).
Conjugation Un-conjugated
Alternate Names IL-17A; Interleukin-17A; IL-17; CTLA8; IL17; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:20 - 1:50
IHC-P1:50 - 1:200
WB1:200 - 1: 1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Rat liver and Mouse liver.


Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.


Database Links

GeneID: 16171 Mouse IL17A

GeneID: 3605 Human IL17A

Swiss-port # Q16552 Human Interleukin-17A

Swiss-port # Q62386 Mouse Interleukin-17A

Gene Symbol IL17A
Gene Full Name interleukin 17A
Background The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
Function Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [UniProt]
Highlight Related products:
IL17 antibodies; IL17 ELISA Kits; IL17 recombinant proteins; Anti-Rabbit IgG secondary antibodies;
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Research Area Cancer antibody; Immune System antibody
Calculated MW 18 kDa
PTM Found both in glycosylated and nonglycosylated forms.

Images (3) Click the Picture to Zoom In

  • ARG55256 anti-IL17 / IL17A antibody IHC image

    Immunohistochemistry: Mouse eyeball tissue stained with ARG55256 anti-IL17 / IL17A antibody.

  • ARG55256 anti-IL17 / IL17A antibody WB image

    Western blot: 25 µg of Rat liver and Mouse liver lysates stained with ARG55256 anti-IL17 / IL17A antibody at 1:1000 dilution.

  • ARG55256 anti-IL17 / IL17A antibody WB image

    Western blot: Extracts of normal (lane 1), retinopathy of prematurity (lane 2) and VEGF/rho transgenic mice (lane 3) stained with ARG55256 anti-IL17 / IL17A antibody.

    Expected signal was at 18 kDa, and the 36 kDa signal in figure might be dimer form of IL17 protein.

Specific References

Cancer-associated fibroblasts promote the migration and invasion of gastric cancer cells via activating IL-17a/JAK2/STAT3 signaling.

IHC-P / Human

Junli Zhang et al.
Ann Transl Med.,  (2020)




Therapeutic Efficacy of Subcutaneous and Intraperitoneal Injections of a Single Dose of Human Umbilical Mesenchymal Stem Cells in Acute and Chronic Colitis in a Mouse Model.

IHC-P / Mouse

Chang Yu‑Lung et al.
Journal of Medical and Biological Engineering.,  (2019)




Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells.

IHC-P / Human

Li Sen et al.
J Exp Clin Cancer Res.,  (2019)