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LAG-3, TIGIT, and TIM-3: key drivers of T cell exhaustion

LAG-3, TIGIT, and TIM-3: key drivers of T cell exhaustion


T cell exhaustion, driven by immune checkpoint proteins, is a key mechanism of tumor immune evasion. Tumor cells express inhibitory ligands such as PD-L1, while T and NK cells upregulate inhibitory receptors including LAG-3, TIGIT, and TIM-3, leading to T cell exhaustion. These checkpoint proteins represent promising targets for immunotherapy. arigo offers quality antibodies to support precise analysis of T cell exhaustion and tumor immunosuppression.

 

LAG3 antibody [SQab22258] (ARG66930)
Immunohistochemistry (IHC-P) staining of human lymphoma tissue using anti-CD223 / LAG-3 antibody [SQab22258], FFPE section with Tris-EDTA antigen retrieval (pH 9.0).

TIGIT antibody [SQab30360] (ARG67087)
Immunohistochemistry: Human tonsil stained with anti-TIGIT antibody [SQab30360]

TIM-3 antibody [SQab22265] (ARG66922)
Immunohistochemistry (IHC-P) staining of human tonsil tissue using anti-TIM-3 antibody, showing TIM-3 expression in formalin-fixed paraffin-embedded sections with Tris-EDTA antigen retrieval (pH 9.0).

 

PD-L1 antibody [SQab1716] (ARG65862)
Immunohistochemistry (IHC-P) staining of human lung adenocarcinoma tissue showing PD-L1 (CD274) expression in formalin-fixed paraffin-embedded sections using anti-PD-L1 antibody, with Tris-EDTA antigen retrieval (pH 9.0).

 

CTLA4 antibody [SQab22255] (ARG66927)
Immunohistochemistry (IHC-P) staining of human lymphoma tissue showing CTLA-4 (CD152) expression in formalin-fixed paraffin-embedded sections using anti-CTLA-4 antibody, with Tris-EDTA antigen retrieval (pH 9.0).

 

CD160 antibody [BY55] (ARG65427)
Flow cytometry analysis of human peripheral blood cells stained with anti-CD160 antibody, followed by incubation with APC-conjugated goat anti-mouse secondary antibody.

 

 

 

More research tools for immunosuppression

 

COX2-PGE2 Axis

PGE2 Competitive ELISA Kit (ARG82995)

COX2 antibody [SQab18107] (ARG66380)

IDO Pathway

Tryptophan ELISA Kit (ARG80483)

Kynurenine ELISA Kit (ARG82779)

IDO1 antibody (ARG59296)

TDO2 antibody (ARG44956)

 

Adenosine axis

Adenosine Assay Kit (ARG83372)

CD39 antibody [A1] (ARG22507)

CD73 antibody [AD2] (ARG55404)

CD38 antibody [SQab20221] (ARG66808)

 

 

 

Solutions for TME visualization

 

Tumor-infiltrating Lymphocyte Antibody Panel (ARG30334)
TIL antibody panel used for IHC-P analysis of CD3, CD4, CD8, and CD20 in FFPE human lymphoid tissues, demonstrating immune cell infiltration in the tumor microenvironment.

Human Inflammatory Cell Antibody Panel (ARG30325)
IHC-P panel showing inflammatory cell markers CD3, CD20, CD68, and MPO expression in human and mouse tissue, detected using the Inflammatory Cell Antibody Panel.

Mouse Inflammatory Cell Antibody Panel (ARG30326)
Mouse inflammatory cell panel used for IHC-P and IHC-Fr detection of Gr-1, F4/80, CD3, and B220, enabling visualization of innate and adaptive immune cell distribution in mouse tissues.

Human CTL / NK Activation Multiplex ELISA Kit (ARG83005)
CTL/NK activation assay panel measuring GrzB, Perforin, IFN-γ, and TNF-α cytokine levels in pg/ml.

CAF Marker Antibody Panel (ARG30347)
CAF marker panel (ARG30347) used for ICC/IF detection of Vimentin, FSP-1, α-SMA, and FAP, demonstrating fibroblast activation and stromal changes associated with tumor microenvironment remodeling.

M1/ M2/ TAM Antibody Panel (ARG30333)
TAM marker panel used for IHC-P detection of CD68, iNOS, CD163, and CD206, enabling visualization of macrophage polarization states (M1-like and M2-like) in human tissues.

 

 

 

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