LAG-3, TIGIT, and TIM-3: key drivers of T cell exhaustion

T cell exhaustion, driven by immune checkpoint proteins, is a key mechanism of tumor immune evasion. Tumor cells express inhibitory ligands such as PD-L1, while T and NK cells upregulate inhibitory receptors including LAG-3, TIGIT, and TIM-3, leading to T cell exhaustion. These checkpoint proteins represent promising targets for immunotherapy. arigo offers quality antibodies to support precise analysis of T cell exhaustion and tumor immunosuppression.

More research tools for immunosuppression

COX2-PGE2 Axis

PGE2 Competitive ELISA Kit (ARG82995)

COX2 antibody [SQab18107] (ARG66380)

IDO Pathway

Tryptophan ELISA Kit (ARG80483)

Kynurenine ELISA Kit (ARG82779)

IDO1 antibody (ARG59296)

TDO2 antibody (ARG44956)

Adenosine axis

Adenosine Assay Kit (ARG83372)

CD39 antibody [A1] (ARG22507)

CD73 antibody [AD2] (ARG55404)

CD38 antibody [SQab20221] (ARG66808)

Solutions for TME visualization

Tumor-infiltrating Lymphocyte Antibody Panel (ARG30334)	Human Inflammatory Cell Antibody Panel (ARG30325)	Mouse Inflammatory Cell Antibody Panel (ARG30326)
Human CTL / NK Activation Multiplex ELISA Kit (ARG83005)	CAF Marker Antibody Panel (ARG30347)	M1/ M2/ TAM Antibody Panel (ARG30333)

LAG-3, TIGIT, and TIM-3: key drivers of T cell exhaustion