SARS-CoV-2 antibodies, proteins, and ELISA kits

The newly identified coronavirus, SARS-CoV-2 (previously known as 2019-nCoV) shares 79.5% sequence identify with SARS-CoV. The viral genome encodes spike, envelope, membrane, nucleocapsid, and multiple non-structural proteins.

arigo offers quality antibodies, proteins, and ELISA kits to facilitate the research of SARS-CoV-2.

HMGB1, a biomarker and therapeutic target in COVID-19

Human anti-SARS-CoV-2 antibody is released

ACE2, receptor of SARS-CoV-2

● Spike protein and ACE2 ●

SARS-CoV-2 cell entry depends on viral spike protein and ACE2 which mediates conversion of Angiotensin II to Angiotensin 1-7. The receptor-binding domain (RBD) of the spike protein is essential for ACE2 binding. Blocking the interaction of spike protein and ACE2 is a potential therapeutic approach for COVID-19 treatment.

● Spike antibodies

Antibody [clone]	Reactivity	Clonality	Application	Cat. No.
Spike [1A9]	SARS-CoV, SARS-CoV-2	Mouse mAb	FACS, FuncSt, WB	ARG11092
Spike (N-terminus)	SARS-CoV	Rabbit pAb	WB	ARG54886
Spike (Center)	SARS-CoV	Rabbit pAb	WB	ARG54885
Spike (SΔ3)	SARS-CoV	Mouse mAb	IP, WB	ARG11094
Spike (S1)	SARS-CoV-2	Rabbit pAb	ELISA, ICC/IF, IHC-P, WB	ARG43344
Spike (S2)	SARS-CoV-2	Rabbit pAb	ICC/IF, IHC-P, WB	ARG43343
Spike (RBD) [SQab20178]	SARS-CoV-2	Mouse mAb	ELISA, FACS, ICC/IF, WB	ARG66740
Spike (RBD)	SARS-CoV-2	Rabbit pAb	ELISA, ICC/IF, IHC-P, WB	ARG43345
Spike (RBD) [CR3022]	SARS-CoV, SARS-CoV-2	Human IgG1	ELISA, ICC/IF, Neut	ARG66739
		Human IgM	ELISA, ICC/IF, Neut	ARG66902
		Human IgA	ELISA, Neut	ARG66903
Spike (RBD)	SARS-CoV, SARS-CoV-2	Rabbit pAb	ICC/IF, WB	ARG11154

● Spike proteins

Product	Expression	Cat. No.
SARS-CoV-2 Spike protein (S1 subunit)	E. coli	ARG70218
SARS-CoV-2 Spike protein (S1 subunit)	HEK293 cell	ARG70345
SARS-CoV-2 Spike protein (S1 subunit) (Fc-fused)	HEK293 cell	ARG70353
SARS-CoV-2 Spike protein (RBD)	E. coli	ARG70219
SARS-CoV-2 Spike protein (RBD)	HEK293 cell	ARG70343
SARS-CoV-2 Spike protein (RBD) (Fc-fused)	HEK293 cell	ARG70349

● ACE2 antibodies

Product	Reactivity	Application	Cat. No.
Mouse anti-ACE2 mAb [AC18F]	Hu	ELISA, FACS, WB	ARG42475
Mouse anti-ACE2 mAb	Hu	WB	ARG54802
Rabbit anti-ACE2 mAb [SQab20231]	Hu	IHC-P	ARG66819
Rabbit anti-ACE2 pAb	Hu, Ms, Rat	IHC-P, IP, WB	ARG41099
Rabbit anti-ACE2 pAb (N-terminus)	Hu	ELISA, ICC/IF, IHC, WB	ARG54914
Rabbit anti-ACE2 pAb (C-terminus)	Hu, Ms, Rat	ELISA, ICC/IF, IHC-Fr, IHC-P, WB	ARG54913
Rabbit anti-ACE2 pAb (Center)	Hu	ICC/IF, IHC-P, WB	ARG55800

● ACE2 proteins

Product	Expression	Cat. No.
Human ACE2 protein (ECD)	HEK293 cell	ARG70351
Human ACE2 protein (ECD) (Fc-fused)	HEK293 cell	ARG70350
Human ACE2 protein (Fc-fused)	CHO cell	ARG70225

● Nucleocapsid protein ●

The nucleocapsid protein is a structural protein required for genomic RNA packaging. It is the most abundant protein in coronavirus and often used as a marker in diagnostic assays.

● Nucleocapsid antibodies

Antibody [clone]	Reactivity	Clonality	Application	Cat. No.
Nucleocapsid [6H3]	SARS-CoV	Mouse mAb	ICC/IF, WB	ARG11091
Nucleocapsid	SARS-CoV-2	Rabbit pAb	ELISA, IHC-P, WB	ARG43346
Nucleocapsid [SQab20177]	SARS-CoV, SARS-CoV-2	Human IgG1	ELISA, ICC/IF, WB	ARG66735
Nucleocapsid [SQab20179]	SARS-CoV, SARS-CoV-2	Human IgM	ELISA, FACS, ICC/IF, WB	ARG66742
Nucleocapsid [SQab20180]	SARS-CoV, SARS-CoV-2	Human IgA	ELISA, FACS, ICC/IF, WB	ARG66741
Nucleocapsid [SQab20210]	SARS-CoV, SARS-CoV-2	Mouse mAb	ELISA, ICC/IF, WB	ARG66782
Nucleocapsid [SQab20212]	SARS-CoV, SARS-CoV-2	Mouse mAb	ELISA, ICC/IF, WB	ARG66796
Nucleocapsid	SARS-CoV, SARS-CoV-2	Rabbit pAb	WB	ARG42478

● Nucleocapsid proteins

Product	Expression	Cat. No.
SARS-CoV-2 Nucleocapsid protein (Tag free)	E. coli	ARG70217
SARS-CoV-2 Nucleocapsid protein	HEK293 cell	ARG70216
SARS-CoV Nucleocapsid protein	HEK293 cell	ARG70215

● Nucleocapsid ELISA kit

Product	Sensitivity	Sample	Cat. No.
SARS-CoV-2 Nucleocapsid protein ELISA Kit	0.171 ng/ml	Cell culture supernatant, nasal swab, saliva	ARG82823
SARS-CoV-2 Nucleocapsid protein ELISA Kit	1.56 ng/ml	Serum, plasma, cell culture supernatant	ARG82688

● E, M and NS proteins ●

● E, M, NS protein antibodies

Antibody [clone]	Reactivity	Clonality	Application	Cat. No.
Envelope protein	SARS-CoV-2	Rabbit pAb	ELISA, IHC-P, WB	ARG43205
Membrane protein	SARS-CoV	Rabbit pAb	ELISA, WB	ARG54884
Membrane protein	SARS-CoV-2	Rabbit pAb	ELISA, IHC-P, WB	ARG43350
NSP2	SARS-CoV-2	Rabbit pAb	ELISA, WB	ARG43352
NSP2	SARS-CoV-2	Rabbit pAb	ELISA, IHC-P	ARG43353
NSP5 / 3CLpro	SARS-CoV-2	Rabbit pAb	ELISA, IHC-P, WB	ARG43303
NSP7	SARS-CoV-2	Rabbit pAb	ELISA, IHC-P, WB	ARG43347
NSP8	SARS-CoV-2	Rabbit pAb	ELISA, WB	ARG43351
NSP9	SARS-CoV-2	Rabbit pAb	ELISA, IHC-P	ARG43348
NSP9	SARS-CoV-2	Rabbit pAb	ELISA, WB	ARG43349
NSP10	SARS-CoV-2	Rabbit pAb	ELISA, IHC-P, WB	ARG43354
RdRp R2 [4E6]	SARS-CoV, SARS-CoV-2	Mouse mAb	WB	ARG11093
NSP13 Helicase	SARS-CoV-2	Rabbit pAb	ELISA, IHC-P	ARG43355
NSP14 ExoN	SARS-CoV-2	Rabbit pAb	ELISA, IHC-P	ARG43356

● E & ORF8 proteins

Product	Expression	Cat. No.
SARS-CoV-2 Envelope protein	E. coli	ARG70346
SARS-CoV-2 ORF8 protein	HEK293	ARG70356

● More Coronavirus reagents ●

● Antibodies

Product	Clonality	Application	Cat. No.
MERS-CoV Spike antibody	Goat pAb	WB	ARG42526
MERS-CoV Nucleocapsid antibody [7H6]	Mouse mAb	ELISA, ICC/IF, IP, WB	ARG11090
Bovine Coronavirus Surface antibody [5A4]	Mouse mAb	ELISA	ARG10284
Feline Coronavirus antibody [FIPV3-70]	Mouse mAb	ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, WB	ARG22654

● Proteins

Product	Expression	Cat. No.
MERS-CoV Nucleocapsid protein	HEK293 cell	ARG70214
HCoV-NL63 Nucleocapsid protein	HEK293 cell	ARG70213
HCoV-OC43 Nucleocapsid protein	E. coli	ARG70221
HCoV-HKU1 Nucleocapsid protein	E. coli	ARG70222
HCoV-229E Nucleocapsid protein	E. coli	ARG70223

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